<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019d3eb4-4167-7c4f-a50a-919801ff7f78,g:92ebf274-ce45-4c54-86f2-9ee586dc0afd-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="simple" xlink:href="medp-20260331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019d3eb4-4231-78a8-ace6-637f6ea153aa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019d3eb4-4231-7d51-8f1f-722939fcf125" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019d3eb4-4231-78a8-ace6-637f6ea153aa" xlink:to="loc_us-gaap_AccountsPayableCurrent_019d3eb4-4231-7d51-8f1f-722939fcf125" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019d3eb4-4231-7e6b-977c-75825ec7fe20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019d3eb4-4231-78a8-ace6-637f6ea153aa" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019d3eb4-4231-7e6b-977c-75825ec7fe20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019d3eb4-4231-7a66-81df-d12d138eb515" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019d3eb4-4231-78a8-ace6-637f6ea153aa" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019d3eb4-4231-7a66-81df-d12d138eb515" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_019d3eb4-4231-781d-9575-df90316a4fa0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019d3eb4-4231-78a8-ace6-637f6ea153aa" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_019d3eb4-4231-781d-9575-df90316a4fa0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019d3eb4-4231-736b-88c6-f777b7834a7f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019d3eb4-4231-7ac6-bb7c-c9599384b95d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019d3eb4-4231-736b-88c6-f777b7834a7f" xlink:to="loc_us-gaap_AssetsCurrent_019d3eb4-4231-7ac6-bb7c-c9599384b95d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019d3eb4-4231-70a6-b70f-87f07e17dce5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019d3eb4-4231-736b-88c6-f777b7834a7f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019d3eb4-4231-70a6-b70f-87f07e17dce5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019d3eb4-4231-7847-acd9-cb1c03668667" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019d3eb4-4231-736b-88c6-f777b7834a7f" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019d3eb4-4231-7847-acd9-cb1c03668667" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019d3eb4-4231-72f0-a071-4c9250732592" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019d3eb4-4231-736b-88c6-f777b7834a7f" xlink:to="loc_us-gaap_Goodwill_019d3eb4-4231-72f0-a071-4c9250732592" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019d3eb4-4231-74c5-a4d8-f5fac8ef261d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019d3eb4-4231-736b-88c6-f777b7834a7f" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019d3eb4-4231-74c5-a4d8-f5fac8ef261d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019d3eb4-4231-79fc-a400-394570558eb7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019d3eb4-4231-736b-88c6-f777b7834a7f" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019d3eb4-4231-79fc-a400-394570558eb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019d3eb4-4231-77c5-af1e-dc3426f5160a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019d3eb4-4231-736b-88c6-f777b7834a7f" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019d3eb4-4231-77c5-af1e-dc3426f5160a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019d3eb4-4231-7c03-a899-5f3edbdd1ca0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019d3eb4-4231-7a68-ade4-c172aa91bff4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019d3eb4-4231-7c03-a899-5f3edbdd1ca0" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019d3eb4-4231-7a68-ade4-c172aa91bff4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_019d3eb4-4231-7cfd-ae5b-f4cd8ff10160" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019d3eb4-4231-7c03-a899-5f3edbdd1ca0" xlink:to="loc_us-gaap_ReceivablesNetCurrent_019d3eb4-4231-7cfd-ae5b-f4cd8ff10160" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019d3eb4-4231-740c-81e1-a72fe7d8fb37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019d3eb4-4231-7c03-a899-5f3edbdd1ca0" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019d3eb4-4231-740c-81e1-a72fe7d8fb37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019d3eb4-4231-71da-8ef7-6303397f0458" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019d3eb4-4231-7e8c-99d3-68462fa71ca7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019d3eb4-4231-71da-8ef7-6303397f0458" xlink:to="loc_us-gaap_Liabilities_019d3eb4-4231-7e8c-99d3-68462fa71ca7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7699-9b8b-cff8a0131dfa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019d3eb4-4231-71da-8ef7-6303397f0458" xlink:to="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7699-9b8b-cff8a0131dfa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019d3eb4-4231-7cef-902c-95024f4d869d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019d3eb4-4231-7e42-8497-c43cf62f16d3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019d3eb4-4231-7cef-902c-95024f4d869d" xlink:to="loc_us-gaap_LiabilitiesCurrent_019d3eb4-4231-7e42-8497-c43cf62f16d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d3eb4-4231-7f3e-8e65-2acb3b12f47f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019d3eb4-4231-7cef-902c-95024f4d869d" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d3eb4-4231-7f3e-8e65-2acb3b12f47f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019d3eb4-4231-7be2-a027-c247c459d7d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019d3eb4-4231-7cef-902c-95024f4d869d" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_019d3eb4-4231-7be2-a027-c247c459d7d2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019d3eb4-4231-719b-a72f-cd878276610c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019d3eb4-4231-7cef-902c-95024f4d869d" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019d3eb4-4231-719b-a72f-cd878276610c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7141-9a30-b064fa89e152" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019d3eb4-4231-7bcc-a10a-15cd0262d5b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7141-9a30-b064fa89e152" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_019d3eb4-4231-7bcc-a10a-15cd0262d5b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019d3eb4-4231-7bdb-a40b-58a8224a979b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7141-9a30-b064fa89e152" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019d3eb4-4231-7bdb-a40b-58a8224a979b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019d3eb4-4231-707b-8c31-227492a2f0e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7141-9a30-b064fa89e152" xlink:to="loc_us-gaap_CommonStockValue_019d3eb4-4231-707b-8c31-227492a2f0e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_019d3eb4-4231-7397-b8d9-941725d63c02" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7141-9a30-b064fa89e152" xlink:to="loc_us-gaap_TreasuryStockCommonValue_019d3eb4-4231-7397-b8d9-941725d63c02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019d3eb4-4231-7ea9-ac7d-ef1e6cd8adbc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7141-9a30-b064fa89e152" xlink:to="loc_us-gaap_PreferredStockValue_019d3eb4-4231-7ea9-ac7d-ef1e6cd8adbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019d3eb4-4231-78d3-823a-69e978c71336" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019d3eb4-4231-7141-9a30-b064fa89e152" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019d3eb4-4231-78d3-823a-69e978c71336" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="simple" xlink:href="medp-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019d3eb4-4231-7f23-a00f-8f71fcf7a979" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DirectOperatingCosts_019d3eb4-4231-75f3-9e5c-072ba75fef69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DirectOperatingCosts"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019d3eb4-4231-7f23-a00f-8f71fcf7a979" xlink:to="loc_us-gaap_DirectOperatingCosts_019d3eb4-4231-75f3-9e5c-072ba75fef69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019d3eb4-4231-75f5-83f0-9823ec343073" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019d3eb4-4231-7f23-a00f-8f71fcf7a979" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019d3eb4-4231-75f5-83f0-9823ec343073" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019d3eb4-4231-73b1-8c3b-87fac133d99f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019d3eb4-4231-7f23-a00f-8f71fcf7a979" xlink:to="loc_us-gaap_Depreciation_019d3eb4-4231-73b1-8c3b-87fac133d99f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019d3eb4-4231-7e1d-a0b7-225b61d4ebd8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_019d3eb4-4231-7f23-a00f-8f71fcf7a979" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019d3eb4-4231-7e1d-a0b7-225b61d4ebd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019d3eb4-4231-724b-b60a-2886d7985a0e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019d3eb4-4231-7834-8280-8f1c9153875e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d3eb4-4231-724b-b60a-2886d7985a0e" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019d3eb4-4231-7834-8280-8f1c9153875e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_019d3eb4-4231-772a-959d-518cd5f9a195" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d3eb4-4231-724b-b60a-2886d7985a0e" xlink:to="loc_us-gaap_CostsAndExpenses_019d3eb4-4231-772a-959d-518cd5f9a195" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019d3eb4-4231-7422-9b9e-851245fbb18f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d3eb4-4231-7364-abf8-b8a9a15fb1d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019d3eb4-4231-7422-9b9e-851245fbb18f" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d3eb4-4231-7364-abf8-b8a9a15fb1d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019d3eb4-4231-79e3-9c18-a55ebf2b47a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019d3eb4-4231-7422-9b9e-851245fbb18f" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019d3eb4-4231-79e3-9c18-a55ebf2b47a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019d3eb4-4231-7156-b7db-cd4b98d52b75" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019d3eb4-4231-7a26-9a8f-7761e3a363fe" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019d3eb4-4231-7156-b7db-cd4b98d52b75" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019d3eb4-4231-7a26-9a8f-7761e3a363fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019d3eb4-4231-774f-93ef-d90482190b8b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019d3eb4-4231-7156-b7db-cd4b98d52b75" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019d3eb4-4231-774f-93ef-d90482190b8b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d3eb4-4231-7cdf-a3b6-a2a2990fcb7f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019d3eb4-4231-76db-876c-483430415052" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d3eb4-4231-7cdf-a3b6-a2a2990fcb7f" xlink:to="loc_us-gaap_OperatingIncomeLoss_019d3eb4-4231-76db-876c-483430415052" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019d3eb4-4231-7537-9596-1f56bbbacd3c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d3eb4-4231-7cdf-a3b6-a2a2990fcb7f" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019d3eb4-4231-7537-9596-1f56bbbacd3c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED" xlink:type="simple" xlink:href="medp-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019d3eb4-4231-706d-8ac9-e40f43c2fdf9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019d3eb4-4231-756f-9ab8-e9b640c35bcf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019d3eb4-4231-706d-8ac9-e40f43c2fdf9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_019d3eb4-4231-756f-9ab8-e9b640c35bcf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019d3eb4-4231-74b7-a163-5fd8b26e9e5d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019d3eb4-4231-706d-8ac9-e40f43c2fdf9" xlink:to="loc_us-gaap_NetIncomeLoss_019d3eb4-4231-74b7-a163-5fd8b26e9e5d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="simple" xlink:href="medp-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUNAUDITED" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019d3eb4-4232-77b2-8dd5-f41767334f3e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_NetIncomeLoss_019d3eb4-4232-77b2-8dd5-f41767334f3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_019d3eb4-4232-7a40-8eb6-d5680cff6301" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_Depreciation_019d3eb4-4232-7a40-8eb6-d5680cff6301" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019d3eb4-4232-771e-97fa-13f7641952a0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019d3eb4-4232-771e-97fa-13f7641952a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019d3eb4-4232-73a0-9fc3-1ab9ca23350e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_ShareBasedCompensation_019d3eb4-4232-73a0-9fc3-1ab9ca23350e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019d3eb4-4232-7396-bbc4-3cc6179965fd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_019d3eb4-4232-7396-bbc4-3cc6179965fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019d3eb4-4232-78f3-b9fe-8ca723d45e06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_019d3eb4-4232-78f3-b9fe-8ca723d45e06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019d3eb4-4232-7892-9bed-4ab21ee7a6a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019d3eb4-4232-7892-9bed-4ab21ee7a6a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_019d3eb4-4232-7ef9-ab47-2cac377551cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_019d3eb4-4232-7ef9-ab47-2cac377551cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019d3eb4-4232-78ba-86e3-611a10eb954a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019d3eb4-4232-78ba-86e3-611a10eb954a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019d3eb4-4232-7252-a6c4-3c0ec083d6cf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019d3eb4-4232-7252-a6c4-3c0ec083d6cf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019d3eb4-4232-7b74-aa7b-c846e6754889" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_019d3eb4-4232-7b74-aa7b-c846e6754889" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019d3eb4-4232-7747-89f4-dea276a8dd0a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019d3eb4-4232-7747-89f4-dea276a8dd0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019d3eb4-4232-7fe1-8cf0-95396d5fbfdb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_019d3eb4-4232-7fe1-8cf0-95396d5fbfdb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019d3eb4-4232-706a-9d30-a53db0b55597" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-7f9c-9faf-9831a5c6d7c7" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet_019d3eb4-4232-706a-9d30-a53db0b55597" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019d3eb4-4232-7475-818e-4b3bae59b7ef" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019d3eb4-4232-7b9b-bc77-5ae8ce311f00" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019d3eb4-4232-7475-818e-4b3bae59b7ef" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019d3eb4-4232-7b9b-bc77-5ae8ce311f00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019d3eb4-4232-7558-bf36-e6023fc89a28" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019d3eb4-4232-7475-818e-4b3bae59b7ef" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_019d3eb4-4232-7558-bf36-e6023fc89a28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019d3eb4-4231-7b03-9661-b61b622d5226" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019d3eb4-4231-7f2b-b814-b12d1b554ec1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019d3eb4-4231-7b03-9661-b61b622d5226" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019d3eb4-4231-7f2b-b814-b12d1b554ec1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-70cd-8319-53dfac975725" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019d3eb4-4231-7b03-9661-b61b622d5226" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019d3eb4-4232-70cd-8319-53dfac975725" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019d3eb4-4232-7194-be4c-b3c9f65fc62a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019d3eb4-4231-7b03-9661-b61b622d5226" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019d3eb4-4232-7194-be4c-b3c9f65fc62a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019d3eb4-4232-75bd-aca8-dc90cbdbc23a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019d3eb4-4231-7b03-9661-b61b622d5226" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019d3eb4-4232-75bd-aca8-dc90cbdbc23a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019d3eb4-4232-722b-9dba-45cfba9a61fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019d3eb4-4232-7f5f-b311-9cf9eebd2a51" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019d3eb4-4232-722b-9dba-45cfba9a61fa" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019d3eb4-4232-7f5f-b311-9cf9eebd2a51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019d3eb4-4232-7589-97eb-6ccfb39b588e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019d3eb4-4232-722b-9dba-45cfba9a61fa" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019d3eb4-4232-7589-97eb-6ccfb39b588e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/ContractAssetsandContractLiabilitiesSummaryofAccountsReceivableandUnbilledNetDetails" xlink:type="simple" xlink:href="medp-20260331.xsd#ContractAssetsandContractLiabilitiesSummaryofAccountsReceivableandUnbilledNetDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/ContractAssetsandContractLiabilitiesSummaryofAccountsReceivableandUnbilledNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_019d3eb4-4232-7cfb-aef0-8e59148d87aa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableGrossCurrent_019d3eb4-4232-7835-9be5-c0d88846ed1b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableGrossCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_019d3eb4-4232-7cfb-aef0-8e59148d87aa" xlink:to="loc_us-gaap_AccountsReceivableGrossCurrent_019d3eb4-4232-7835-9be5-c0d88846ed1b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnbilledReceivablesCurrent_019d3eb4-4232-7d96-8819-425f3f9a8f1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_UnbilledReceivablesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_019d3eb4-4232-7cfb-aef0-8e59148d87aa" xlink:to="loc_us-gaap_UnbilledReceivablesCurrent_019d3eb4-4232-7d96-8819-425f3f9a8f1e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_019d3eb4-4232-7b2b-a998-2f956fb7dc04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ReceivablesNetCurrent_019d3eb4-4232-7cfb-aef0-8e59148d87aa" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_019d3eb4-4232-7b2b-a998-2f956fb7dc04" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/IntangibleAssetsNetScheduleofIntangibleAssetsNetDetails" xlink:type="simple" xlink:href="medp-20260331.xsd#IntangibleAssetsNetScheduleofIntangibleAssetsNetDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/IntangibleAssetsNetScheduleofIntangibleAssetsNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-785a-9b37-749dd915315e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019d3eb4-4232-7f17-bb8e-48bba62521ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-785a-9b37-749dd915315e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019d3eb4-4232-7f17-bb8e-48bba62521ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019d3eb4-4232-7d2a-a7f2-db529b28b4c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-785a-9b37-749dd915315e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019d3eb4-4232-7d2a-a7f2-db529b28b4c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019d3eb4-4232-7485-9203-6f1941695b48" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-79fa-b6fa-a4928ff09a5a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019d3eb4-4232-7485-9203-6f1941695b48" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-79fa-b6fa-a4928ff09a5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedTradeNames_019d3eb4-4232-7c15-9471-581d2da93836" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IndefiniteLivedTradeNames"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019d3eb4-4232-7485-9203-6f1941695b48" xlink:to="loc_us-gaap_IndefiniteLivedTradeNames_019d3eb4-4232-7c15-9471-581d2da93836" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/IntangibleAssetsNetScheduleofEstimatedAmortizationExpenseofIntangibleAssetsDetails" xlink:type="simple" xlink:href="medp-20260331.xsd#IntangibleAssetsNetScheduleofEstimatedAmortizationExpenseofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/IntangibleAssetsNetScheduleofEstimatedAmortizationExpenseofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-7707-a450-5beb963de76a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019d3eb4-4232-73f2-805a-e6c8d31c249a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-7707-a450-5beb963de76a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019d3eb4-4232-73f2-805a-e6c8d31c249a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019d3eb4-4232-7ae8-b11c-7d764e2d7a16" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-7707-a450-5beb963de76a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019d3eb4-4232-7ae8-b11c-7d764e2d7a16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019d3eb4-4232-7e4d-818c-30474ceed35b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019d3eb4-4232-7707-a450-5beb963de76a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019d3eb4-4232-7e4d-818c-30474ceed35b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/AccruedExpensesDetails" xlink:type="simple" xlink:href="medp-20260331.xsd#AccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/AccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019d3eb4-4232-7203-be89-820c6f97a5f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019d3eb4-4232-7cea-b063-cbb9afe743e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d3eb4-4232-7203-be89-820c6f97a5f7" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019d3eb4-4232-7cea-b063-cbb9afe743e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_medp_ProjectRelatedReimbursableExpensesLiabilitiesCurrent_019d3eb4-4232-7a2f-a6db-a18a547c356d" xlink:href="medp-20260331.xsd#medp_ProjectRelatedReimbursableExpensesLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d3eb4-4232-7203-be89-820c6f97a5f7" xlink:to="loc_medp_ProjectRelatedReimbursableExpensesLiabilitiesCurrent_019d3eb4-4232-7a2f-a6db-a18a547c356d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019d3eb4-4232-74fa-9530-f00defd1fc0c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d3eb4-4232-7203-be89-820c6f97a5f7" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019d3eb4-4232-74fa-9530-f00defd1fc0c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/LeasesSummaryofSupplementalBalanceSheetInformationRelatedtoLeasesDetails" xlink:type="simple" xlink:href="medp-20260331.xsd#LeasesSummaryofSupplementalBalanceSheetInformationRelatedtoLeasesDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/LeasesSummaryofSupplementalBalanceSheetInformationRelatedtoLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019d3eb4-4232-77a2-bbb8-556bc762a8f0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d3eb4-4232-7d04-991a-6a1611aadbe5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019d3eb4-4232-77a2-bbb8-556bc762a8f0" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d3eb4-4232-7d04-991a-6a1611aadbe5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d3eb4-4232-7956-8cd3-7317dbd8a77b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019d3eb4-4232-77a2-bbb8-556bc762a8f0" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d3eb4-4232-7956-8cd3-7317dbd8a77b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="medp-20260331.xsd#LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7e95-b902-323a8409fc88" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019d3eb4-4232-7bdd-8a1d-38ad8374d8c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7e95-b902-323a8409fc88" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019d3eb4-4232-7bdd-8a1d-38ad8374d8c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019d3eb4-4232-78fa-bebd-a88aacd592ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7e95-b902-323a8409fc88" xlink:to="loc_us-gaap_OperatingLeaseLiability_019d3eb4-4232-78fa-bebd-a88aacd592ad" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.medpace.com/role/LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="medp-20260331.xsd#LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.medpace.com/role/LeasesScheduleofLeasePaymentsDueRelatedToLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7d0e-aac0-05f5312dbf58" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019d3eb4-4232-79e4-8105-e9ecacfee805" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7d0e-aac0-05f5312dbf58" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019d3eb4-4232-79e4-8105-e9ecacfee805" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019d3eb4-4232-794c-bb74-09454b379a06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7d0e-aac0-05f5312dbf58" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019d3eb4-4232-794c-bb74-09454b379a06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019d3eb4-4232-74af-b0bc-cc4d87323ded" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7d0e-aac0-05f5312dbf58" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019d3eb4-4232-74af-b0bc-cc4d87323ded" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019d3eb4-4232-7020-85e6-e25ef4dbe056" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7d0e-aac0-05f5312dbf58" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019d3eb4-4232-7020-85e6-e25ef4dbe056" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019d3eb4-4232-7605-a96e-aee2cee66041" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7d0e-aac0-05f5312dbf58" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019d3eb4-4232-7605-a96e-aee2cee66041" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_medp_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_019d3eb4-4232-7c61-9dd7-60619e026ccd" xlink:href="medp-20260331.xsd#medp_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d3eb4-4232-7d0e-aac0-05f5312dbf58" xlink:to="loc_medp_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_019d3eb4-4232-7c61-9dd7-60619e026ccd" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
